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KMID : 0363420200340010037
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Journal of Korean Oriental Pediatrics
2020 Volume.34 No. 1 p.37 ~ p.47
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Genistein Recovers Dermatitis Damage through Endocannabinoid System (ECS) Activity
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Ahn Sang-Hyun
Seo Il-Bok
Kim Ki-Bong
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Abstract
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Objectives: After inducing dermatitis in 6-week-old mice, we tried to find out the effects of recovery in the damaged skin by administering genistein and palmitoylethanolamide (PEA)
Methods: The 6-week-old mice were divided into the control group (Ctrl), dermatitis causing group (AcDE), genistein-administered group after the onset of dermatitis (GsT), and PEA-administered group after the onset of dermatitis (PEAT). Seven mice were assigned to each group. Changes in the skin barrier were observed after three days of administration following the onset of dermatitis.
Results: In the GsT and PEAT, there was less skin damage compared to the AcDE, and the lowest skin damage showed in the GsT. The intensity of CB1 and CB2 expression was increased by 64% (CB1) and 39% (CB2) in the GsT, and 38% (CB1) and 28% (CB2) in the PEAT compared to the AcDE. The E-catherin positive reaction was decreased in the AcDE, while the E-catherin positive reaction was increased in the GsT (76%) and PEAT (34%). The p-JNK positive reaction was increased in the AcDE, while the p-JNK positive reaction was decreased in the GsT (60%) and PEAT (39%). Toxic Hepatopathy was not observed in the liver tissue of Genistein administered 3OGsT, and PEA administered 3OPEAT.
Conclusions: Genistein has recovery effect on dermatitis damage through active induction of the endocannabin system (ECS).
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KEYWORD
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Genistein, dermatitis, Endocannabinoid system (ECS), CB1, CB2, p-JNK
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